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Twilio

Add custom AI voices to your Twilio call flows. Power IVR automation, personalized outbound calls, and real-time deepfake detection on your telephony stack.

How it works

YOUR APP
Twilio Call Flow
Inbound or outbound call triggers via Twilio webhook
+
RESEMBLE AI
Voice Synthesis
Custom AI voice generated in real-time with low latency
+
YOUR APP
Deepfake detection
Audio on the call scanned for synthetic voice spoofing
OUTPUT
Caller experience
Personalized, secure, and branded voice delivered

Overview

Resemble AI integrates natively with Twilio's telephony infrastructure, letting you replace robotic TTS with custom AI voices that sound exactly like your brand or a real person. Whether you're building IVR menus, outbound notification systems, or AI-powered phone agents, this integration drops into your existing Twilio setup with no infrastructure changes.

For security-conscious deployments, the integration also supports Resemble Detect our multimodal deepfake detection layer which can flag AI-generated or cloned voices on inbound calls in real time, protecting your agents and customers from voice spoofing fraud.

Features

Custom AI voice synthesis

Clone your brand voice or build a new one. Deliver consistent, human-sounding speech across every call with sub-second latency.

Real-time streaming TTS

Stream audio directly into Twilio's <Play> and <Say> verbs. No pre-rendered files needed — generate speech dynamically per call.

Deepfake detection on calls

Run Resemble Detect on inbound audio to identify AI-generated or cloned voices before they reach your agents.

Multilingual support

Generate speech across 90+ languages and accents. Localize IVR flows or outbound campaigns without separate voice talent.

Inbound and outbound calls

Works with both Twilio inbound webhooks and outbound call APIs. Handle any direction of call with the same voice profile.

HIPAA and GDPR ready

All audio processing is compliant with healthcare and data privacy requirements. Suitable for regulated industries.

Use cases

  • Replace generic TTS in IVR menus with a branded, human-sounding AI voice
  • Power outbound notification calls (appointment reminders, billing alerts) with dynamic voice generation
  • Build AI phone agents that use your brand's voice for customer-facing conversations
  • Detect voice spoofing attacks on inbound calls to protect financial or healthcare workflows
  • Localize call center operations across multiple languages without hiring voice talent per region
  • A/B test different voice personas on Twilio call flows using Resemble's voice management API

Quick start

Point your Twilio webhook at Resemble's streaming TTS endpoint and pass the text you want spoken. The integration returns audio Twilio can play directly in a call.

# 1. Install the Resemble Python SDK
pip install resemble

# 2. In your Twilio webhook handler:
from resemble import Resemble
from twilio.twiml.voice_response import VoiceResponse, Play

Resemble.api_key('YOUR_RESEMBLE_API_KEY')

def twilio_webhook(request):
    response = VoiceResponse()

    # Generate speech from Resemble
    audio_url = Resemble.v2.clips.create_sync(
        project_uuid='your-project-uuid',
        voice_uuid='your-voice-uuid',
        body='Hello! How can I help you today?',
    )

    # Play the audio in the Twilio call
    response.play(audio_url)
    return str(response)

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